Polymorphism COX-1 to Platelet Aggregation in Coronary Heart Disease Patients
Polimorfisme COX-1 terhadap Agregasi Platelet pada Pasien Penyakit Jantung Koroner
AbstractThe Genetic Polymorphism of COX-1 (Cyclooxygenase 1) is one of the factors causing variations in theresponse to platelet aggregation. These variations can cause Coronary Artery Disease (CAD) in patientswith Coronary Heart Disease. This cross-sectional research was conducted at Sidoarjo General Hospital inEast Java from November to December 20217. This observational research was used for checking the COX1 polymorphism with Polymerase Chain Reaction (PCR) and platelet aggregation with the LightTransmittance Aggregonetry (LTA) method for measuring platelet aggregation. Majority of patients involvedin this research were 45-64 years (93.34%), men (53.33%), and overweight (80.00%). From 30 patientsinvolved in this study, 13.33% showed homozygote (wild type) COX-1 polymorphisms and 86.67% showedheterozygote COX-1 polymorphisms. The majority patients with homozygot and heterozygot polymorphismsshowed normo aggregation with 75.00% and 84.62%, subsequently. Statistical analysis with Mann Whitneyshowed that there is no relationship between COX-1 polymorphisms and platelet aggregation (p= 0.423).Further research should be conducted to explore other factors that contribute to platelet aggregation.
Copyright (c) 2021 Charliandri Saputra Wahab, J. Nugroho Eko Putranto, Ike Dhiah Rochmawati
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