Polymorphism COX-1 to Platelet Aggregation in Coronary Heart Disease Patients

Polimorfisme COX-1 terhadap Agregasi Platelet pada Pasien Penyakit Jantung Koroner

  • Charliandri Saputra Wahab Universitas Surabaya
  • J. Nugroho Eko Putranto Rumah Sakit Umum Dr. Soetomo
  • Ike Dhiah Rochmawati Universitas Surabaya
Keywords: Platelet aggregation, Coronary artery disease, COX-1 polymorphism

Abstract

The Genetic Polymorphism of COX-1 (Cyclooxygenase 1) is one of the factors causing variations in theresponse to platelet aggregation. These variations can cause Coronary Artery Disease (CAD) in patientswith Coronary Heart Disease. This cross-sectional research was conducted at Sidoarjo General Hospital inEast Java from November to December 20217. This observational research was used for checking the COX1 polymorphism with Polymerase Chain Reaction (PCR) and platelet aggregation with the LightTransmittance Aggregonetry (LTA) method for measuring platelet aggregation. Majority of patients involvedin this research were 45-64 years (93.34%), men (53.33%), and overweight (80.00%). From 30 patientsinvolved in this study, 13.33% showed homozygote (wild type) COX-1 polymorphisms and 86.67% showedheterozygote COX-1 polymorphisms. The majority patients with homozygot and heterozygot polymorphismsshowed normo aggregation with 75.00% and 84.62%, subsequently. Statistical analysis with Mann Whitneyshowed that there is no relationship between COX-1 polymorphisms and platelet aggregation (p= 0.423).Further research should be conducted to explore other factors that contribute to platelet aggregation.
Published
2021-01-19
How to Cite
Wahab, C. S., Putranto, J. N. E., & Rochmawati, I. D. (2021). Polymorphism COX-1 to Platelet Aggregation in Coronary Heart Disease Patients: Polimorfisme COX-1 terhadap Agregasi Platelet pada Pasien Penyakit Jantung Koroner. Journal of Pharmacy and Science, 6(1), 31-35. https://doi.org/10.53342/pharmasci.v6i1.203