Effervescent Granule Formulation of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) Antin 3 Variety As an Antioxidant Nutraceutical
Formulasi Granul Effervescent Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin 3 Sebagai Nutraceutical Antioksidan
Keywords:
Antin 3 extract, Effervescent granules, PVP K-30, CMC Na, Physical characteristic
Abstract
Antin 3 variety of purple sweet potato (Ipomoea batatas L.) leaf extract contains flavonoids and polyphenols as antioxidants so that have the potential to be used as nutraceuticals. Effervescent granules have acidic and basic components which can react with water to form CO2 so that it can covering the taste of extract and is able to give a fresh taste. There are two formulas with different types of binders, namely PVP K30 5% (F1) and CMC Na 1.5% (F2). The granulation method used is wet granulation. The effervescent granule tests carried out were organoleptic, particle size distribution, flow rate, angle of repose, Hausner's ratio, compressibility index, dispersion time test, foam height, moisture content, pH and hedonic test. The evaluation results obtained were that F1 and F2 did not have significant differences in the values of moisture content, Hausner's ratio and compressibility index. F1 and F2 had significant differences in the values of flow rate, pH and dispersibility time. F1 had the hedonic test results ( color, aroma and taste) which were more preferable. F1 had dispersibility time and foam height values which did not meet the requirements while F2 meets the requirements.References
1. Dipahayu D, Kusumo Gondo G. Antioxidant Activity, Phenolic and Flavonoid Contents in The Leaves Extract of Purple Sweet Potatoes (Ipomoea batatas L.) Antin-3 Variety in Different Ethanol Concentration as a Solvent. 3 rd Jt Conf Unair-USM, Int Conf Pharm Heal Sci 2020 Non Proceeding. 2020;
2. Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010;15(11):7792–814.
3. Sriarumtias FF. Formulasi Granul Effervescent Ekstrak Pandan Laut (Pandanus tectorius Parkinson ex Du Roi) Sebagai Analgetik. Pharmauho J Farm Sains, dan Kesehat. 2020;6(2):60.
4. J LVA, HCA. Pharmaceutical Dosage Form and Drug Delivery System 10 th edition. S H, editor. Philadelphia: Wolters Kluwer Health; 2014.
5. Kailaku SI, Sumangat J, Hernani. Formulasi Granul Efervesen Kaya Antioksidan Dari Ekstrak Daun Gambir. J Pascapanen. 2012;9(1):27–34.
6. Palobo FN, Yamlean PVY, Yudistira A, Unsrat FF. Formulasi Granul Effervescent Ekstrak Daun Leilem (Clerodendrum minahassae L). Pharmacon UNSRAT. 2012;1(2):64–71.
7. Kartikasari R, Astuti Yuni I, Dwi H. Formula Granul Instan Ekstrak Temulawak (Curcuma Xanthorriza Roxb) Dengan Kombinasi Gelatin Dan Dekstrin. Pharm J Farm Indones. 2009;06(01):86–100.
8. Rahmawati IF, Pribadi P, Hidayat IW. Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.). Pharmaciana. 2016;6(2).
9. Rahmi W. Formulasi Suspensi Kering Efervesen Ekstrak Akar Acalypha indica Linn. Menggunakan Pati Ganyong Terpregelatinasi Sebagai Eksipien Secara Granulasi Peleburan. Univ Indones. 2009;112.
10. Rowe et al. Poloxamer : Handbook of Pharmaceutical Excipients, Sixth Edition. Handb Pharm Excipients, Sixth Ed. 2009;110–3.
11. Diniatik, Astuti IY, Apriani R. Pegal linu adalah rasa nyeri pada bagian tertentu yang dapat timbul karena kelelahan setelah bekerja, olah raga, dan sebagainya atau merupakan suatu gejala penyakit seperti masuk angin, pilek, dan sebagainya. Simplisia penyusun diperlukan yang mempunyai k. Pharmacy. 2010;07(02):77–89.
2. Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010;15(11):7792–814.
3. Sriarumtias FF. Formulasi Granul Effervescent Ekstrak Pandan Laut (Pandanus tectorius Parkinson ex Du Roi) Sebagai Analgetik. Pharmauho J Farm Sains, dan Kesehat. 2020;6(2):60.
4. J LVA, HCA. Pharmaceutical Dosage Form and Drug Delivery System 10 th edition. S H, editor. Philadelphia: Wolters Kluwer Health; 2014.
5. Kailaku SI, Sumangat J, Hernani. Formulasi Granul Efervesen Kaya Antioksidan Dari Ekstrak Daun Gambir. J Pascapanen. 2012;9(1):27–34.
6. Palobo FN, Yamlean PVY, Yudistira A, Unsrat FF. Formulasi Granul Effervescent Ekstrak Daun Leilem (Clerodendrum minahassae L). Pharmacon UNSRAT. 2012;1(2):64–71.
7. Kartikasari R, Astuti Yuni I, Dwi H. Formula Granul Instan Ekstrak Temulawak (Curcuma Xanthorriza Roxb) Dengan Kombinasi Gelatin Dan Dekstrin. Pharm J Farm Indones. 2009;06(01):86–100.
8. Rahmawati IF, Pribadi P, Hidayat IW. Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.). Pharmaciana. 2016;6(2).
9. Rahmi W. Formulasi Suspensi Kering Efervesen Ekstrak Akar Acalypha indica Linn. Menggunakan Pati Ganyong Terpregelatinasi Sebagai Eksipien Secara Granulasi Peleburan. Univ Indones. 2009;112.
10. Rowe et al. Poloxamer : Handbook of Pharmaceutical Excipients, Sixth Edition. Handb Pharm Excipients, Sixth Ed. 2009;110–3.
11. Diniatik, Astuti IY, Apriani R. Pegal linu adalah rasa nyeri pada bagian tertentu yang dapat timbul karena kelelahan setelah bekerja, olah raga, dan sebagainya atau merupakan suatu gejala penyakit seperti masuk angin, pilek, dan sebagainya. Simplisia penyusun diperlukan yang mempunyai k. Pharmacy. 2010;07(02):77–89.
Published
2023-07-28
How to Cite
Dipahayu, D. (2023). Effervescent Granule Formulation of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) Antin 3 Variety As an Antioxidant Nutraceutical: Formulasi Granul Effervescent Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin 3 Sebagai Nutraceutical Antioksidan. Journal Pharmasci (Journal of Pharmacy and Science), 8(2), 167-172. https://doi.org/10.53342/pharmasci.v8i2.369
Section
Articles
Copyright (c) 2023 Damaranie Dipahayu
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