Epigallocatechin gallate Cream Formulation For Anti Aging

Formulasi  Krim Epigallocatechin gallate Sebagai Anti Aging

Abstract

Premature aging is a big problem for a woman. Early aging can cause a feeling of lack of confidence. Signs
of premature aging include the appearance of black spots, fine lines appear, pores appear to be enlarged,
dull, the face feels rough, the eyes change shape, facial skin relaxes and even skin discoloration can occur.
Many factors can trigger premature aging, namely excessive sun exposure, sleeping position, consumption of
unhealthy foods and drinks, the skin lacks rest because it always wears makeup, stressful, sleep deprivation
and genetics. Premature aging can be prevented by using anti-aging cosmetics. One of the substances that
can be used as an anti-aging is epigallocatechin gallate. Epigallocatechin gallate is a compound from
natural ingredients that has antioxidant activity. The antioxidant activity of epigallocatechin gallate is
higher than that of vitamin C and vitamin E. Epigallocatechin gallate is a high antioxidant (100 times
vitamin C or 25 times vitamin E). This study aims to formulate anti-aging creams with active ingredients
epigallocatechin gallate with different concentrations of cream bases so as to obtain anti-aging creams with
optimal physical characteristics. Cream base is the main excipient material in forming the consistency of a
cream preparation. In this study the cream base used is lexemul CS-20 where the cream base contains a
combination of 2 cream bases namely cetearyl alcohol and ceteareth-20). Researchers hope that using only
one ingredient can provide optimal results. In this study, we want to know the effect of base cream
concentration on the physical characteristics of epigallocatechin gallate cream. The base cream
concentrations used are 10%, 15% and 20%. The results showed that the F1, F2 and F3 formulas were
organoleptically the same white and homogeneous, only that the F1 formula was slightly runny. Based on
the results of the pH test on the formula F1, F2 and F3 give no significant difference. All formulas are creams with oil-in-water type emulsions. The higher concentration of cream base gives a higher viscosity
value, conversely the higher the concentration of cream base the smaller the spread of cream. Based on the
stability test with the centrifugation method F1 formula looks unstable because the preparation separates
into 2 phases, whereas in formulas F2 and F3, the preparation does not separate (stable).