Formulation and Evaluation of Hydrogel from Agarwood Leaf (Aquilaria malacensis Lamk.) Ethanol Extract with Carbopol 940 and HPMC K4M Combination

Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M

Abstract

Hydrogel is a topical preparation by applying it to the skin. Agarwood leaf extract is proven to contain
flavonoid compounds which play a role in helping the wound healing process. The combination of carbopol
and HPMC intend to cover the deficiency of carbopol when used at high concentrations and to provide an
acidic ph. Knowing the effect of the combination of carbopol 940 and HPMC K4M bases and the results of
the stability evaluation of the optimal hydrogel formulation of agarwood leaf ethanol extract. The method
used is experimental with true-experimental design. The sample used is gaharu leaves taken from Tanah
Bumbu Regency. The data were then analyzed using the ANOVA statistical LSD and Kruskal-Wallis tests.
The hydrogel formulation with a combination of carbopol 940 and HPMC K4M bases had an effect on the
hydrogel formulation of gaharu leaf extract on organoleptic stability, homogeneity, pH, viscosity,
dispersibility and adhesion. The formula that maintains the stability of the evaluation during 28 days of
storage at room temperature is Formulation 2 (F2). The statistical test results of pH, viscosity, spreadability
and adhesion <0.05, p-value <0.05 showed a significant difference in the five formulas, with concentration
P1 (carbopol 940 0.75%), P2 (HPMC K4M 0.75%), for F1, F2 and F3 combinations of carbopol 940 and
HPMC K4M respectively (0.25%: 0.5%), (0.375%: 0.375%) and (0.5%: 0.25 %).