The Correlation Between Potential Antidiabetic Side Effects And Risk Factors In Type 2 Diabetes Mellitus Patients at Hospital Lamongan
Hubungan Kejadian Efek Samping Potensial Antidiabetes Dengan Faktor Risiko Pasien Diabetes Melitus Tipe 2 Di RS Lamongan
DOI:
https://doi.org/10.53342/pharmasci.v10i1.464Keywords:
Diabetes Mellitus, Hypoglycemia, Age, Gender, Body Mass IndexAbstract
Diabetes mellitus is a metabolic disease caused by abnormalities in insulin performance and/or insulin secretion. Risk factors for side effects of drugs need to consider aspects of age, gender, and body mass index. This study aims to determine the relationship between potential side effects of antidiabetics and risk factors for type 2 diabetes mellitus. This study was conducted at Lamongan Hospital during the period January-March 2024. The study design used a cross-sectional design with data collection from patient medical records and the results of interviews filling out the naranjo questionnaire. The population in this study was 95 patients. The sample was selected using a purposive sampling technique and 89 patients met the inclusion criteria. Based on the results of the study, the most common potential side effect of antidiabetes was hypoglycemia experienced by 25 patients (28.08%) with the dominant number of hypoglycemia side effects due to the use of insulin actrapid (11.23%). The naranjo score results showed probable (89.89%) which means that the possibility of complaints in the form of hypoglycemia in patients is a side effect of antidiabetes. Hypoglycemia is characterized by a decrease in blood glucose levels <70 mg/dl (<4.0 mmol/L). Signs of hypoglycemia that appear in patients are trembling, hunger, nausea, and dizziness. Data analysis using the Spearman Rank Correlation test showed a significant relationship between the occurrence of potential side effects of Antidiabetics with age risk factors (p=0.004) and did not have a significant relationship with gender risk factors (p=0.553) and body mass index (p=0.473). The presence of age factors due to changes in physiology and body biochemistry, is closely related to increased glucose intolerance which is at risk of insulin resistance. Education of health workers, especially from Pharmacists, determines the success of therapy and prevention of drug-related problems including drug side effects.
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Joddy Sutama Putra, R., Achmad, A., & Rachma Pramestutie, H. (2017). Kejadian Efek Samping Potensial Terapi Obat Anti Diabetes Pada Pasien Diabetes Melitus Berdasarkan Algoritme Naranjo. Pharmaceutical Journal of Indonesia, 2(2), 45–50. https://doi.org/10.21776/ub.pji.2017.002.02.3
Khairinnisa, A., & Yusmaini, H. H. (2020). Perbandingan Penggunaan Glibenclamid-Metformin dan Glimepirid-Metformin Terhadap Efek Samping Hipoglikemia Pasien Diabetes Melitus Tipe-2. Seminar Nasional Riset Kedokteran (SENSORIK), Dm, 147–154.
Komariah, K., & Rahayu, S. (2020). Hubungan Usia, Jenis Kelamin Dan Indeks Massa Tubuh Dengan Kadar Gula Darah Puasa Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Pratama Rawat Jalan Proklamasi, Depok, Jawa Barat. Jurnal Kesehatan Kusuma Husada, Dm, 41–50. https://doi.org/10.34035/jk.v11i1.412
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PERKENI. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Global Initiative for Asthma, 46.
Putri Maria Natasya Panamuan, A., Kartika Untari, E., Rizkifan Program Studi Farmasi, S., Kedokteran, F., & Tanjungpura Jl Hadari Nawawi, U. (2021). Pengaruh Usia Pasien dan Dosis terhadap Efek Samping Metformin pada Pasien Diabetes Tipe 2. Jurnal Farmasi Komunitas, 8(2), 51–58.
Riwu, M., Subarnas, A., & Lestari, K. (2015). The Correlation of Age Factor, Administration, and Metformin Dose Against Risk of Side Effect on Type 2 Diabetes Mellitus. Indonesian Journal of Clinical Pharmacy, 4(3), 151–161. https://doi.org/10.15416/ijcp.2015.4.3.151
Rumi, A., Aulia, R., & Tandah, M. R. (2023). Identifikasi Kejadian Adrverse Drug Reactions pada Penggunaan Amlodipin di Instalasi Rawat Jalan RSUD Undata. Majalah Farmaseutik, 19(3), 409–416.
Utami, P. R., & Octavia, D. R. (2022). Study of potential interactions of oral antidiabetic drugs in patients with type 2 diabetes mellitus with comorbidities: A retrospective study. Pharmacy Education, 22(2), 200–206. https://doi.org/10.46542/pe.2022.222.200206
Zhu, M., Liu, X., Liu, W., Lu, Y., Cheng, J., & Chen, Y. (2021). ? Cell Aging and Age-Related Diabetes. Aging, 13(5), 7691–7706. https://doi.org/10.18632/aging.202593
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