The Effect of a Combination of Bay Leaves and Cloves in Mouthwash Preparations in the Antibacterial Activity of Streptococcus mutans: Pengaruh Kombinasi Daun Salam dan Cengkeh dalam Sediaan Obat Kumur Terhadap Aktivitas Antibakteri Streptococcus mutans

Cicik  Wijayanti; Lyrra Mirna  Amanda; Nabilah Rosdiana Maulana; Yuke Pramudita Sari; Khoirul Ngibad; Ali  Abraham

doi:10.53342/pharmasci.v10i2.530

Authors

Cicik Wijayanti Universitas Maarif Hasyim Latif Sidoarjo
Lyrra Mirna Amanda Universitas Maarif Hasyim Latif Sidoarjo
Nabilah Rosdiana Maulana Universitas Maarif Hasyim Latif Sidoarjo
Yuke Pramudita Sari Universitas Maarif Hasyim Latif Sidoarjo
Khoirul Ngibad Universitas Maarif Hasyim Latif Sidoarjo
Ali Abraham Universitas Islam Indonesia Yogyakarta

DOI:

https://doi.org/10.53342/pharmasci.v10i2.530

Keywords:

Bay leaf,, Streptococcus mutans,, clove oil,

Abstract

Streptococcus mutans is a bacteria that can damage teeth. This study aims to determine the effect of the combination of bay leaf extract and clove oil in herbal mouthwash on Streptococcus mutans and to measure the inhibition zone of each formulation. Bay leaf extract was obtained through the maceration method, while the antibacterial test used the disc diffusion method. Formulation 1 contains 1% bay leaves and 5 ml of cloves; Formulation 2 has 2% bay leaves and 7.5 ml of cloves; Formulation 3 consists of 3% bay leaves and 10 ml of cloves. The positive control used Listerine, and the negative control used distilled water. The evaluation included organoleptic tests, pH, homogeneity, stability, and viscosity. The results of the organoleptic test showed a green liquid preparation with a spicy aroma and a sweet and bitter taste. All three formulations had a pH of 6.5, classified as homogeneous and stable. The viscosity test showed a range of 48.5-158.5 mPa.s. Antibacterial test showed inhibition zone in Formulation 1 of 9.33 mm, Formulation 2 of 15.49 mm, and Formulation 3 of 10.35 mm. The formulation has great potential as an alternative herbal mouthwash with strong ability to inhibit the growth of Streptococcus mutans.

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