Physical Stability Test of Bakuchiol Oil and Bakuchiol Encapsulated Cream: Uji Stabilitas Fisik Formula Krim Bakuchiol Oil dan Bakuchiol Encapsulated

Eliza Stepanie Romadhona; Christina  Avanti; Mediana  Hadiwidjaja; Agnes Nuniek  Winantari; Ni Luh Dewi  Aryani

doi:10.53342/pharmasci.v9i1.425

Authors

Eliza Stepanie Romadhona Departemen Farmasi, Fakultas Farmasi, Universitas Surabaya
Christina Avanti Departemen Farmasi, Fakultas Farmasi, Universitas Surabaya
Mediana Hadiwidjaja Departemen Farmasi, Fakultas Farmasi, Universitas Surabaya
Agnes Nuniek Winantari Departemen Farmasi, Fakultas Farmasi, Universitas Surabaya
Ni Luh Dewi Aryani Departemen Farmasi, Fakultas Farmasi, Universitas Surabaya

DOI:

https://doi.org/10.53342/pharmasci.v9i1.425

Keywords:

Bakuchiol Oil, Bakuchiol Encapsulated, Cream, Stability

Abstract

Loss of elasticity, fine lines and wrinkles on the skin are signs of aging that are often encountered. The purpose of this study was the evaluation of the physical stability of bakuchiol oil cream and encapsulated bakuchiol at 25Â°C for 30 days. This research was carried out experimentally. The tests observed are organoleptic homogeneity, emulsion type, dispersion and pH. Organoleptic test results are analyzed descriptively, while measurements other than organoleptic are analyzed with independent t-test statistics using Statistical Product and Service Solutions (SPSS) software. The results of this study obtained that organoleptic, bakuchiol oil cream showed beige color, cream shape, distinctive fruit odor, homogeneous, M/A type, 50g dispersion power of 5.9 cm, 250g dispersion power of 7.47 cm, and pH of 7.5. While the test results of organoleptic encapsulated bakuchiol cream showed white, cream shape, odorless, homogeneous, type M/A, physical characteristics showed a dispersion power of 50 g of 5.23cm, a dispersion of 250g of 6.97cm and a pH of 7.61. The stability test results show that the formula of bakuchiol oil and bakuchiol encapsulated meets the requirements of good cream stability. The results of statistical tests provide a significant difference between the two cream.

References

1. Shin S, Lee JA, Son D, Park D, Jung E. Anti-skin- aging activity of a standardized extract from panax ginseng leaves in vitro and in human volunteer. Cosmetics. 2017;4(2).
2. Chaudhuri RK, Bojanowski K. Bakuchiol: A retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int J Cosmet Sci. 2014;36(3):221â€“30.
3. Wang J, Luo M, Shen J, Liu Z, Chen Y, Luo J, et al. Bakuchiol from Psoralea corylifolia L. Ameliorates acute kidney injury and

improves survival in experimental polymicrobial sepsis. Int Immunopharmacol [Internet]. 2020;89(September):107000. Available from:
https://doi.org/10.1016/j.intimp.2020.10700 0
4. Eskens O, Amin S. Challenges and effective routes for formulating and delivery of epidermal growth factors in skin care. Int J Cosmet Sci. 2021;43(2):123â€“30.
5. Sakamoto K, Lochhead RY, Maibach HI, Yamashita Y. Cosmetic Science and Technology: Theoretical Principles and Applications. Cosmetic Science and Technology: Theoretical Principles and Applications. 2017. 1â€“835 p.
6. Lestari FA, Hajrin W, Hanifa NI. Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin. J Kefarmasian Indones. 2020;10(2):110â€“9.
7. Mitsui T. New Cosmetc Science. First Edition. Elsevier Sci BV. 1997;13â€“21.
8. Lumentut N, Edi HJ, Rumondor EM. Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya.
9. Zam Zam AN, Musdalifah M. Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator. J Syifa Sci Clin Res. 2022;4(2):304â€“13.

10. Mailana D, Nuryanti, Harwoko. Formulasi Sediaan Krim Antioksidan Ekstrak Etanolik Daun Alpukat (Persea americana Mill.). Acta Pharm Indones. 2016;4(2):7â€“15.
11. Khuranna, D.; Sharma, S.; Mir, S.R.; Aqil, M.;
Ahmad, A.; Rehman, M.U.; Ahmad, P.; Alwahibi, M.S.; Elshikh, M.S.; Mujeeb, M. Extraction, quantification, and cytokine inhibitory response of bakuchiol in Psoralea coryfolia Linn. Separations 2020, 7, 48.
12. Uikey, S.K.; Yadav, A.S.; Sharma, A.K.; Rai, A.K.; Raghuwanshi, D.K.; Badkhane, Y. The botany, chemistry, pharmacological and therapeutic application of Psoralea corylifolia L.: A review. Int. J. Phytomed. 2010, 2, 100â€“107
13. S D, shaheda SA, Basha SR, Pasha SE, Jilani S. Formulation and evaluation of Antiwrinkle activity of Cream and Nano emulsion of Moringa oleifera seed oil. IOSR J Pharm Biol Sci. 2014;9(4):58â€“73.
14. Ratnapuri PH, Sari DI, Ihsanuddin MF. Karakteristik Fisika dan Kimia Sediaan Krim Ekstrak Kulit Bawang Merah (Allium ascalonicum) dengan Variasi Konsentrasi Ekstrak. Pros Semin. 2020;5(April):36â€“41