Effect Of Isopropyl Palmitate Composition As Liquid Lipid On The Physical Characteristics Of Nanostructured Lipid Carrier (NLC) Coenzyme Q10: Pengaruh Komposisi Isopropyl Palmitat sebagai Lipid Cair terhadap Karakteristik Fisik Sediaan Nanostructured Lipid Carrier (NLSC) Koenzim Q10

Silvi Ayu Wulansari; Lamtiur  Nainggolan; Denis Alifia  Azzahro; Azka Nur  Khoirun; Andhika Dwi  Aristyawan

doi:10.53342/pharmasci.v11i1.540

Authors

Silvi Ayu Wulansari Akademi Farmasi Surabaya
Lamtiur Nainggolan Akademi Farmasi Surabaya
Denis Alifia Azzahro Akademi Farmasi Surabaya
Azka Nur Khoirun Akademi Farmasi Surabaya
Andhika Dwi Aristyawan Akademi Farmasi Surabaya

DOI:

https://doi.org/10.53342/pharmasci.v11i1.540

Keywords:

Nanostructured Lipid Carrier,, Koenzim Q10,, Isopropyl palmitat,

Abstract

Coenzyme Q10 is naturally found in mitochondria, functioning as an antioxidant to protect the body from free radicals. One preparation that can increase its stability is Nanostructured Lipid Carrier (NLC). NLC is a drug delivery system that uses a combination of solid lipids and liquid lipids stabilized by surfactants. This study aims to determine the composition of Isopropyl palmitate on the physical characteristics of the NLC Coenzyme Q10 preparation. In this study, the formulation of NLC Coenzyme Q10 preparation was made with varying concentrations of liquid lipids Isopropyl palmitate F1 2%, F2 3% and F3 4% solid lipid Cetyl palmitate 12% with the active ingredient Coenzyme Q10. The finished NLC preparation was stored for 24 hours to conduct physical characteristic tests including organoleptic tests, homogeneity, pH, and spreadability. Based on the results of organoleptic testing, the three formulas have met the specified specifications, namely having a semi- solid form, pale yellow in color and odorless, and showing good homogeneity. The test results showed that variations in the composition of isopropyl palmitate did not significantly affect the pH value or spreadability of the NLC coenzyme Q10 preparation (p>0.05). Based on the results of this study, it can be concluded that differences in the composition of liquid lipids in the NLC Coenzyme Q10 preparation did not affect the physical characteristics test.

References

1) Kalangi, Sonny JR. Histofisiologi Kulit. Bagian Anatomi-Histologi Fakultas Kedokteran Universitas Sam Ratulangi Manado. J Biomedik. 2013;5(3):12–20.

2) Handayani R, Kautsar AP. Strategi Baru Sistem Penghantaran Obat Transdermal Menggunakan Peningkat Penetrasi Kimia. Farmaka. 2018;15(3):24–36.

3) Bagiana IK. Sekolah Tinggi Ilmu Farmasi “ Yayasan Pharmasi Semarang ” Tahun Anggaran 2020. 2020;1–9.

4) Sarifuddin N, Hardia L. Pengaruh Konsentrasi Asam Hialuronat Terhadap Karakteristik Fisik Koenzim Q10 Dalam Sistem Nanostructured Lipid Carrier (NlC). J Etnofarmasi. 2021;(1):1–6.

5) Vica Aspadiah, Sitti Nuraisyah Wahyuningrum Af. Penggunaan Lipid Asam Stearat Dalam Sistem Penghantaran Obat Berbasis Nanopartikel. 2020;8(75):147–54.

6) Khasanah U, Rochman MF. Stabilitas Nanostructured Lipid Carrier Koenzim Q10 Dengan Variasi Waktu Pengadukan. J Ilmu Farm dan Farm Klin. 2022;18(2):55.

7) Aryani NLD, Siswandono, Soeratri W, Putri DY, PuspitasariniPD. Development, Characterization In Vitro And In Silico Of Coenzyme Q10 Loaded Myristic Acid With Different Liquid Lipids Nanostructured Lipid Carrier. J Pharm Pharmacogn Res. 2021;9(5):573–83.

8) Rohmah M, Raharjo S, Hidayat C, Martien R. Formulasi Dan Stabilitas Nanostructured Lipid Carrier. Dari Campuran Fraksi Stearin Dan Olein Minyak Kelapa Sawit. J Apl Teknol Pangan. 2019 Feb 28;8(1)

9) Fransisca D:, Mayangsari D. Uji Karakteristik Fisik Dan Stabilitas Fisik Sleeping Mask Yang Mengandung NLC-Coq10 Dan Minyak Nilam Sebagai Kosmetik Anti-Penuaan Kulit Fransisca.

10) Muthoharoh L, Ratna Rianti D. Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Daun Kelor (Moringa Oleifera L.). J Kefarmasian Akfarindo. 2020 Mar 30;27–35.

11) Farmasetika M, Penelitian A, Rohmah H, Pratiwi ED, Mayangsari FD, Farmasi P, Et Al. Pengaruh Probiotik Terhadap Karakteristik Dan Stabilitas Fisik Serum NLC Koenzim Q10. 2025;10(1):45–56.

12) Erwiyani AR, Luhurningtyas FP, Sunnah I. Optimasi Formula Sediaan Krim Ekstrak Etanol Daun Alpukat (Persea Americana Mill ) Dan Daun Sirih Hijau (Piper Betle Linn). Cendekia J Pharm. 2017;1(1):77–86.