Physical Quality Stability Test and Antibacterial Activity Test of Face Toner Roll On Formulation of Centella Asiatica (L.) Urb. Leaf Extract Againts Propionibacterus acnes

Elpi Lutpiani; Luluk Aniqoh  Meliana Putri

doi:10.53342/pharmasci.v11i1.585

Authors

Elpi Lutpiani Universitas Strada Indonesia
Luluk Aniqoh Meliana Putri Universitas Strada Indonesia

DOI:

https://doi.org/10.53342/pharmasci.v11i1.585

Keywords:

Activity , Antibacterial, Face Toner Roll On, Propionibacterium acnes, Physical Quality Stability

Abstract

Acne affects all ages, from teenagers to adults, and is generally caused by bacteria. One of the main causes is Propionibacterium acnes, a gram-positive bacterium that lives in the skin and sebaceous follicles. Therefore, a natural solution for treating acne is gotu kola leaves, which are blended into a liquid roll-on face toner. Its flavonoids, tannins, saponins, and alkaloids act as antibacterial agents against Propionibacterium acnes. This study used a laboratory experiment. The results showed that the physical stability test of gotu kola leaf extract roll-on face toner (Centella asiatica (L.) urb) in formulation 1 (7.5%), formulation 2 (10%), and formulation 3 (12.5%) successfully withstood the test, maintained stable pH and viscosity, and exhibited no significant changes in color and odor upon storage. The gotu kola leaf extract roll-on face toner demonstrated very strong antibacterial activity against Propionibacterium acnes. Formula F3 (12.5%) had the largest inhibition zone diameter of 46.27 mm. However, based on ANOVA and post hoc tests, there was no significant difference between F2 (10%) and F3 (12.5%) compared to the positive control (sig > 0.05), so both formulas had comparable antibacterial effectiveness to the positive control.), so that both formulas had antibacterial effectiveness comparable to the positive control.

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