Bioactive Compounds and Efficacy of Ethyl Acetate Extract of Coriandrum sativum L. as Antioxidants and Antimicrobials
Kandungan Senyawa Bioaktif dan Efektivitas Ekstrak Etil Asetat Coriandrum sativum L. sebagai Antioksidan dan Antimikroba
DOI:
https://doi.org/10.53342/pharmasci.v11i2.588Keywords:
Coriandrum sativum,, etil asetat,, Gc-Ms,, antioksidan,, antimikroba,Abstract
Coriander seeds (Coriandrum sativum L.) have potential as traditional medicine due their potential as a natural source of antioxidants and antimicrobials. This study aimed to identify the bioactive compounds present, as well as to evaluate the antioxidant and antimicrobial activities of the ethyl acetate extract of coriander seeds (Coriandrum sativum L.). Compound identification was performed using Gas Chromatography-Mass Spectrometry (GC-MS), whilst antioxidant activity was tested using the DPPH method, and antimicrobial activity was tested against Staphylococcus aureus and Candida albicans using the disc diffusion method. The GC-MS results showed three dominant compounds with the highest peak areas, namely linalool (75.92%), camphor (3.68%), and geranyl acetate (2.67%). The antioxidant assay yielded an IC?? value of 708 µg/mL with a maximum inhibition percentage of 16.3724% at a concentration of 200 µg/mL, which is classified as very weak. In the antimicrobial test against Staphylococcus aureus, variations in the concentration of the ethyl acetate extract of coriander seeds showed an effect on the diameter of the inhibition zone; the higher the concentration, the larger the resulting inhibition zone tended to be. Statistical analysis also indicated significant differences between certain concentrations, particularly 250 ppm and 1000 ppm. Meanwhile, the antimicrobial test against Candida albicans showed that variations in the concentration of the coriander seed ethyl acetate extract did not result in significant differences in the diameter of the inhibition zones produced.
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